METABOLIC ANALYSIS OF THE MODE OF ACTION AND MODE OF RESISTANCE FOR NOVOBIOCIN IN STAPHYLOCOCCUS AUREUS

Abstract: Novobiocin is an aminocoumarin antibiotic that targets DNA gyrase, a critical enzyme involved in bacterial DNA replication. In Staphylococcus aureus, resistance to novobiocin is increasingly observed, necessitating a comprehensive metabolic analysis of both its mechanism of action and resistance pathways. This study explores the metabolic

Introduction Transient ischemic attacks (TIAs), often referred to as "mini-strokes," are temporary episodes of neurological dysfunction caused by ischemia without acute infarction. Early and accurate diagnosis of TIA is crucial to prevent subsequent strokes, yet clinical diagnosis remains challenging due to the transient nature of symptoms and the